Combined use of nicotine patch and gum in smoking cessation: a placebo- controlled clinical trial. Hence, nicotine replacement therapy by way of gum, patch, or spray has been advocated. The rationale of this study is to evaluate the possible beneficial effects of adding nicotine gum to the routine of subjects using the nicotine patch. The effect of the nicotine patch against the placebo, both groups receiving placebo nicotine gum, has also been assessed. METHODS: Healthy subjects (3. Treatment duration was 1. Gum use was not restricted during the first 6 months, with recommendations to use at least four pieces a day. A strict definition of smoking abstinence was used in this study, which did not allow smoking any cigarette after Week 1. Nonsmoking status at each visit, as reported by the subjects, was verified by CO below 1. RESULTS: Abstinence rates in group 1 against group 2 were 3. P = 0. 0. 27) at 1. P = 0. 0. 10) at 2. P = 0. 1. 91) at 5. In group 3, abstinence rates were 1. Using logistic regression with adjustment for six baseline covariates, odds ratios for abstinence (with 9. CI) were computed. For group 1/group 2, OR at 1. P = 0. 0. 39), 2. P = 0. 0. 18), and 1. P = 0. 1. 25). No significant differences in OR were observed when comparing groups 2 and 3.
Nicotine gum is a type of. Alternative nicotine replacement products include the nicotine patch. Users are directed to chew the gum until it softens and. NRT products (patch, gum). Time to relapse is significantly longer in group 1 as compared to that of group 2 (P = 0. No significant differences between the three groups in systemic and local adverse drug events were observed. CONCLUSION: Adding active gum use to active patch use in subjects smoking 1.
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January 2017
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